122348 -

Based on recent scientific literature from late 2025/early 2026, the number refers specifically to the total count of Differentially Methylated Regions (DMRs) identified in a comprehensive study of colorectal adenoma subtypes.

Colorectal Adenoma Subtypes Exhibit Signature Molecular Profiles 122348

The study identified these 122,348 genomic regions as having significantly different methylation patterns (adding or removing methyl groups, which changes gene expression) between various colorectal adenoma (precancerous polyp) subtypes and normal tissue. 122,348. Hypermethylated regions (Gene silencing): 6,263. Hypomethylated regions (Gene activation): 116,050. Based on recent scientific literature from late 2025/early

These DMRs suggest that DNA methylation changes are a crucial, early event in colorectal tumorigenesis, acting before severe morphological changes occur in the cells. Hypermethylated regions (Gene silencing): 6,263

The researchers used these 122,348 regions to create unique methylation "signatures" for different types of adenomas—specifically Sessile Serrated Lesions (SSL), Traditional Serrated Adenoma (TSA), and VA/TVA (Villous/Tubulovillous Adenoma).