The paper investigates how excess RA triggers its own degradation (via Cyp26 enzymes) and how depletion leads to compensatory receptor expression.

You can find the full text and original figures on the Wiley Online Library .

The identifier appears to refer to a specific archived dataset or supplement associated with the scientific paper "Input overload: Contributions of retinoic acid signaling feedback to retinoid homeostasis" (published in Developmental Dynamics ). Full Paper Details

Input overload: Contributions of retinoic acid signaling feedback to retinoid homeostasis Authors: Andrea Janesick, Bruce Blumberg, and others.

It discusses the role of Retinoic Acid Response Elements (RAREs) in promoters as sensors that modulate the expression of retinoid-related genes.