This technique was detailed in the established protocol paper featured in STAR Protocols , which allows researchers to execute high sequencing depth of mouse brain vascular cells to study brain diseases. The Role of ApoE4 and Cerebrovascular Function
One of Yamazaki’s most notable technical contributions to the scientific community is her work on profiling the transcriptomics of the blood-brain barrier. akari yamazaki
: Her research published in journals like Arteriosclerosis, Thrombosis, and Vascular Biology has demonstrated that ApoE in Brain Pericytes regulates endothelial cell phenotype. This showed that ApoE4 impairs the basement membrane formation of capillaries, contributing to cognitive decline. This technique was detailed in the established protocol
Yamazaki's chemical research frequently focuses on and related fused-ring systems. Azulene is known for its deep blue color and unusual dipole moment, making its derivatives highly sought after for advanced materials and pharmaceuticals. This showed that ApoE4 impairs the basement membrane
In the field of neurology, Akari Yamazaki is a prominent research researcher at the Mayo Clinic Department of Neuroscience. Her work primarily revolves around understanding how the brain's complex vascular systems intersect with neurodegenerative diseases like Alzheimer's disease (AD). Pioneering Brain Vascular Profiling