: Bifunctional agents can link two DNA bases together (interstrand or intrastand cross-linking), which prevents the DNA strands from separating for replication.
: The drug attaches an "alkyl group" to a DNA base, most frequently at the N7 position of guanine . alkalating agent
The primary goal of these agents is to disrupt the DNA replication process. They achieve this through a process called : : Bifunctional agents can link two DNA bases
: Once the DNA damage becomes too severe to repair, the cell's internal checkpoints trigger programmed cell death (apoptosis). From old alkylating agents to new minor groove binders They achieve this through a process called :
Alkylating agents are a critical class of chemotherapy drugs that act directly on the DNA of cells to prevent them from growing and dividing. Unlike many other cancer treatments, they are , meaning they can attack cancer cells at any stage of their life cycle. How They Work