G8046.mp4

: The protein G3BP (GTPase-activating protein-binding protein) acts as a central "node" or switch for granule formation.

, showing purified G3BP and RNA forming droplets in a controlled laboratory setting. g8046.mp4

: When the cell is stressed, unfolded RNA molecules bind to G3BP, causing it to expand and cluster together. This leads to the formation of liquid-like droplets (condensates) that sequester mRNA. Usage in the Study unfolded RNA molecules bind to G3BP

of stress granules forming in living HeLa cells. G3BP is in a compact

: Under normal conditions, G3BP is in a compact, "auto-inhibited" state.

, such as droplets fusing together or recovering after being bleached by a laser (FRAP).