The , produced from 2006 to 2013 , is widely considered one of the finest luxury flagships of its era, marking a significant return to form for Mercedes after the reliability criticisms of the previous W220 model. While it offers exceptional comfort and pioneering technology, it requires a "luxury maintenance" budget to remain reliable on the used market. Key Highlights
: The cabin replaced many plastic surfaces with higher-end leather, wood, and metal. High-end options include massaging seats with four modes and active ventilation. Engine Options & Reliability MERCEDES S-CLASS W221 1.45
: An advanced adaptive cruise control that can bring the car to a full stop in traffic. The , produced from 2006 to 2013 ,
: Predicts collisions and can automatically apply maximum braking pressure. produced from 2006 to 2013