While an episode titled "The Sacrifice" occurs in Season 2, Season 6 Episode 13 is a significant turning point for the series. You and I (and Obi-Wan and Anakin) Are Gonna Live Forever
The episode ends with Yoda receiving a prophecy about " another Skywalker " and accepting that while the Jedi may lose the Clone War, there is a "path unknown to the Sith" for long-term victory. [S6E13] Sacrifice
This episode originally served as the series finale for several years. It concludes Yoda’s journey to discover the secret of immortality. While an episode titled "The Sacrifice" occurs in