The narrative progresses through over 30 main missions, including:
: The story follows four roommates who are struggling to pay off their student loans and survive in a city ruled by lawless factions. The narrative progresses through over 30 main missions,
: After being cast out of their respective organizations, the four friends decide to "be their own boss" and form The Saints . They set up operations in a derelict church and work to take over nine city districts from rival gangs. The narrative progresses through over 30 main missions,
: An art major and former mechanic for Los Panteros who serves as the group's driver. The narrative progresses through over 30 main missions,
: Anarcho-communists focused on neon-soaked nightlife.