Because TG2 is implicated in chronic conditions like cancer and neurodegeneration (such as Huntington's and Alzheimer's), it is now a hot target for new therapeutic drugs designed to selectively inhibit its activity without harming healthy cells.

🔬 TG2: The Molecular "Swiss Army Knife" Shaping Cellular Fate

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When things go wrong, TG2 shifts roles. In the extracellular space, it binds to integrins and acts as a co-receptor, facilitating cell adhesion and migration.

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Often referred to as tissue transglutaminase, TG2 is a multifunctional, Ca²⁺-dependent protein that acts far beyond a simple crosslinker. It’s an enzyme that wears many hats:

TG2 acts as a "molecular glue," crosslinking extracellular collagen and fibronectin to help stabilize tissue structure, making it vital for wound healing.

Inside the cell, TG2 contributes to survival pathways. However, its dysregulation is linked to celiac disease, fibrosis, and tumor progression, making it a critical player in disease research.