It allows for the observation of neural interactions across widely distributed cortical areas, which was previously challenging due to FOV limitations.

It achieves cellular resolution across an ultra-large FOV exceeding 50 mm².

Experiments have shown its capability to study both morphology (structural) and neuronal activity (functional) in mouse brains. 4. Implementation and Data Handling

Capable of visualizing neuronal activity across a spatial range of over 7 mm. 2. Components of the Adaptive System

Utilizes a deformable mirror to correct for system-level nonlinearities and optical aberrations, enabling sharp imaging across the entire 50 mm² area.

It allows researchers to visualize brain structures spanning from superficial layers down to 900 μm depth in a single study.

The system described in the 2026 publications (often referred to as the ULTRA system) provides an unprecedented combination of field-of-view (FOV) and depth. Multi-scale in vivo neuronal imaging.

Custom-written software, frequently using LabVIEW 2020 (National Instruments).